Michael Bradley had given the United States the lead after just six minutes when a Javier “Chicharito” Hernandez error finished with the Toronto FC man unleashing a superb lob over Guillermo Ochoa.
That the set the tone for an entertaining first half, in which El Tri looked to threaten with build-up play, making them the most dangerous side.
Mexico finally managed to penetrate the United States defense in the 23rd minute when a quick break from Chicharito found Carlos Vela with space down the right to fire in the equalizer.
In the second half, after a brief spell of dominance from the home side, the United States turned up the tempo, but in truth, rarely tasted in the Mexican defense.
In the 70th minute, El Tri came close to taking the lead when Hector Herrera rattled the woodwork from a free-kick. The United States replied almost immediately, as Bradley also hit the post from a long-range shot.
Moments later, Mexico were given a chance to score from closer in, but the U.S. defense was alert to clear a dangerous Hirving Lozano diagonal.
At the end, with the United States pegged back, the final result was a point for both teams.
The draw leaves Mexico on the brink of World Cup qualification with 14 points, while the United States earned their eighth point in the Hexagonal.