In a rematch of the 2014 Liga MX Apertura final, Club America and Tigres will face off again but this time in the final of the CONCACAF Champions League.
In Nuevo Leon, Andre-Pierre Gignac scored twice to help Tigres secure a 2-0 victory over Queretaro.
After a goalless first leg, the game started evenly-matched and closely fought with neither side allowed time to dwell on the ball.
But after Jesus Dueñas went off for Tigres with a red card, Ricardo "Tuca" Ferretti's side turned the pressure on and Andre-Pierre Gignac received a deflected pass from Damian Alvarez to fire home the breakthrough.
Gignac then sealed Tigres' place in the final when he drove in between two defenders and slid the ball behind Tiago Volpi to score the 2-0.
Meanwhile, Club America took a huge step towards successfully defending their CONCACAF Champions League title with a 1-0 home win over Santos Laguna.
After a goalless first half, in which Oribe Peralta and Darwin Quintero came close to grabbing a breakthrough, both teams went into the break scoreless.
A sterile opening to the second half followed, but the game came to life when Darwin Quintero was sent off for Club America in the closing stages of the regular period.
Playing all of extra time a man short, Club America's goal came in the 102nd minute. Agustin Marchesin saw a seemingly easy Michael Arroyo free-kick slip through his hands in embarrassing fashion and into the back of the net to give Las Aguilas the lead.
Dario Benedetto then threatened to double America's lead when forcing one of his shots into the woodwork, but Las Aguilas survived a late Santos push to hold on to the 1-0 victory.
The first leg of the CONCACAF Champions League final between Club America and Tigres will be on April 20 at the Estadio Universitario, while Las Aguilas will host the return leg at the Estadio Azteca on April 27.