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Mexican internationals Hector Herrera and Miguel Layun started for FC Porto, as the Portuguese side suffered their third straight defeat in Europe with a 2-0 loss to Borussia Dortmund on Thursday.
Working as a center back for the first time in his career, Miguel Layun couldn't prevent Dortmund from controlling possession from the start. Lukasz Piszczek slipped through to breach the Porto area before heading in his own rebound on six minutes and give the German side the lead.
Reus then doubled the advantage 17 minutes from time after a great some great passing from Shinji Kagawa and Hendrikh Mkhitaryan led to the German international firing past Iker Casillas for the 2-0.
The victory hands Dortmund a 2-0 advantage heading towards the second leg at the Estádio do Dragão. Jesus "Tecatito" Corona saw the game from the bench.
Elsewhere, Jonathan Dos Santos received the start in Villarreal's 1-0 win over Napoli but left the match in the 36th minute through injury.
The Mexican midfielder was seen hobbling off the field and holding his hamstring before eventually being carted off by Villarreal's medical staff.
The only goal of the match was scored by Denis Suarez when he scored a brilliant free-kick in the 81st minute to give the Yellow Submarine an important victory at home.
Alan Pulido played the last nine minutes in Olympiacos' 1-0 defeat to Anderlecht. Kara Mbodji's 67th minute strike was enough to give the Belgian side a 1-0 advantage ahead of the second leg in Greece.
Finally, Javier "Chicharito" Hernandez remained sidelined through injury, but that didn't stop the Werkself from earning a crucial victory at Sporting.
Karim Bellarabi channeled his inner-Chicharito to score off a Tin Jedvaj cross to give Bayer an away goal advantage for the second leg.