After Friday's 3-0 win over El Salvador, Juan Carlos Osorio will look to continue the good results against an Honduras side that lost 1-0 to Canada in their qualifying opener.
Given Honduras' sluggish start to qualifying, it's tempting to see Mexico's prospects in a more tranquil light. But El Tri have not won a qualifier in Honduran soil in 22 years.
Mexico's last away win in Honduras came in 1993 -- a 4-1 win with Alberto Garcia Aspe, Luis Flores and Luis Garcia on the scoresheet for the Mexicans.
It is a disappointing record to have from a team with the resources to do better, but to be fair, away fixtures in CONCACAF are never easy.
Still, this is new coach Osorio's chance of gaining visibility back in Mexico. The doubts over his appointment would surely only intensify with a loss, but with a convincing away performance, things would look more optimistic for the Colombian.
At the moment, though, the stakes are higher for Honduras. A negative result at home combined with a Canada win could complicate their way towards Russia 2018.
One thing is for certain, the atmosphere will be electric at the Estadio Olimpico Metropolitano. It is an early must-win for Honduras, while Mexico is out to get their first win there in more than two decades.
Match date/time: Tuesday 4:00pm EST, 3:00pm local
Venue: Estadio Olimpico Metropolitano, San Pedro Sula, Honduras
TV: beIN Sports USA (US), Telemundo (US- Spanish), NBC Universo (US - Spanish) Azteca 7 (Mexico), UnivisionTDN (Mexico), TDN (Mexico), Canal 5 Televisa (Mexico),
Radio: Futbol de Primera (US)