The match began with high intensity from both sides as both teams sought to win the ball and go on the attack from the opening whistle.
But it was Chile who surprised the Mexicans and opened the scoring in the 39th minute. Brian Leiva headed towards goal from a corner to beat Abraham Romero and give the hosts the lead.
However, Mexico replied immediately and leveled the score two minutes later. Following a great play from Kevin Magana, Claudio Zamudio swept home in front of goal to keep Mexico's quarterfinal hopes alive.
Already in the second half. Pablo Lopez fired Mexico into the lead when he unleashed a left-footed strike to the bottom corner of the net.
In the 69th minute, Eduardo Aguirre scored a third for El Tri, as Mario Arteaga's side looked set to complete the feat.
Diego Cortes finished off a memorable afternoon for Mexico by adding a fourth in added time to give the young El Tri side a comprehensive victory.